功能
This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase
and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is
secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and
hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide
parathion. Polymorphisms in this gene may be associated with coronary artery disease and
diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on
chromosome 7.
