背景
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction
of glucose and lysine residues (glycation). Proteins modified in this way are less active or
functional. This gene encodes an enzyme which catalyzes the phosphorylation of
psicosamines and ribulosamines compared to the neighboring gene which encodes a highly
similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity
of both enzymes may result in deglycation of proteins to restore their function. Alternative
splicing results in multiple transcript variants.
