背景
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The
protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor
of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family
members are known to be cytokine-inducible negative regulators of cytokine signaling. The
expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells.
Proteasome-mediated degradation of this protein has been shown to be involved in the
inactivation of the erythropoietin receptor. Multiple transcript variants encoding different
isoforms have been found for this gene.
