背景
This gene encodes a member of the sorting nexin family. Members of this family contain a
phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded
protein does not contain a coiled coil region, like some family members, but does contain a
SRC homology domain near its N-terminus. The encoded protein is reported to have a
variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase nonreceptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded
protein is implicated in several stages of intracellular trafficking, including endocytosis,
macropinocytosis, and F-actin nucleation.
