背景
This gene encodes a member of the SWI/SNF family, whose members have helicase and
ATPase activities and are thought to regulate transcription of certain genes by altering the
chromatin structure around those genes. The encoded protein is part of the large ATPdependent chromatin remodeling complex SNF/SWI, which is required for transcriptional
activation of genes normally repressed by chromatin. It possesses at least two conserved
domains that could be important for its function. First, it has a DNA-binding domain that can
specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at
the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid
receptor-dependent transcriptional activation. It is thought that the protein encoded by this
gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets
through either protein-DNA or protein-protein interactions. Two transcript variants encoding
different isoforms have been found for this gene.
