背景
The protein encoded by this gene is a member of the serine/threonine kinase family. This
kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially
activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway.
This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is
found to be involved in the transcription activity of NF-kappaB mediated by Rho family
GTPases and CDC42.
