背景
This gene is a member of the septin family of nucleotide binding proteins, originally
described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in
yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption
of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells.
This gene is highly expressed in brain and heart. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. One of the isoforms (known
as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and
cancer.
