背景
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-
tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The
cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein)
coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent,
stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to
be involved in the cannabinoid-induced CNS effects (including alterations in mood and
cognition) experienced by users of marijuana. Multiple transcript variants encoding two
different protein isoforms have been described for this gene.
