免疫原
Recombinant protein (or fragment).This information is considered to be commercially
sensitive.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
ATF; QPD; UPA; URK; u-PA; BDPLT5; PLAU
背景
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The
encoded preproprotein is proteolytically processed to generate A and B polypeptide chains.
These chains associate via a single disulfide bond to form the catalytically inactive high
molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be
further processed into the catalytically active low molecular weight urokinase-type
plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the
urokinase-type plasminogen activator receptor. Mutations in this gene may be associated
with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results
in multiple transcript variants, at least one of which encodes an isoform that is
proteolytically processed.
