基因名称(Gene Name)
DHX15 DBP1 DDX15
蛋白名称
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (ATP-dependent RNA helicase #46) (DEAH box protein 15)
免疫原
Synthesized peptide derived from human DHX15
特异性
This antibody detects endogenous levels of DHX15 at Human, Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
RNA helicase involved in mRNA processing and antiviral innate immunity . Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA . In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns . Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome . Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) . Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses . The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu . Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).
