背景
This gene encodes a member of the F-box protein family which is characterized by an
approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four
subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function
in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes:
Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing
either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript
variants have been found for this gene, but the full-length nature of some variants has not
been determined.
