背景
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of
NAD from tryptophan, and has been implicated in the pathogenesis of several
neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can
divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from
ACMS.
