免疫原
Recombinant protein (or fragment).This information is considered to be commercially
sensitive.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
LDLCQ7; NPC11L1; SLC65A2; Niemann-Pick type C1 Like-1
背景
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved
N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD)
which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network
transport signal in other proteins. This protein takes up free cholesterol into cells through
vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It
also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this
protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition,
this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in
this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol
(LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
