背景
This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG
trinucleotide repeats are implicated in many disorders as they often act as transcription- and
translation-regulatory elements, can produce hairpin structures which cause DNA replication
errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for
CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription,
this gene is believed to play a role in DNA damage repair and telomere protection. In vitro
studies indicate this protein does not bind to methylated CpG sequences.
