背景
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide Nacetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucintype O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to
serine and threonine residues on target proteins. They are characterized by an N-terminal
transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif
and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have
different, but overlapping, substrate specificities and patterns of expression. The encoded
protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast
cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
