背景
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral
membrane proteins composed of an alpha chain and a beta chain. This protein combines
with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivatedC3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of
the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated
endothelium cells, and in the phagocytosis of complement coated particles. Two transcript
variants encoding different isoforms have been found for this gene.
