背景
The protein encoded by this gene belongs to a highly conserved cAMP-regulated
phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the
sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive
potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta
cells and plays a key role in the control of insulin release from pancreatic beta cells. This
protein is thought to be an endogenous regulator of KATP channels. In vitro studies have
demonstrated that this protein modulates insulin secretion through the interaction with KATP
channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least
eight alternatively spliced transcript variants encoding distinct isoforms have been
observed.
