免疫原
Synthetic peptide. This information is considered to be commercially sensitive.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
This gene encodes a type II transmembrane protein that belongs to the interferon-induced
transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface
hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate
size fragments before internalization and degradation in the lysosome. It also has an
interferon-mediated antiviral function in humans through activation of the JAK STAT signaling
pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has
been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally
occurring mutations in this gene are associated with autosomal recessive non-syndromic
hearing loss.
