背景
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR)
family. The encoded protein is thought to function as an integrator of transcriptional
repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional
activity of peroxisome proliferator activated receptors alpha and gamma, though evidence
for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be
variable but is typically relatively low. Knockout studies in mice suggested a role for this
protein in myelination of the corpus callosum, lipid metabolism, differentiation, and
epidermal cell proliferation. Alternative splicing results in multiple transcript variants
encoding distinct protein isoforms.
