背景
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins
with a classical nuclear localization signal. The protein encoded by this gene is a member of
a class of approximately 20 potential Ran targets that share a sequence motif related to the
Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along
with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene.
