背景
This gene encodes a member of the F-box protein family, members of which are
characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins
constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-
cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich
repeats, and Fbxs containing either different protein-protein interaction modules or no
recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition
to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants
encoding distinct isoforms have been identified for this gene
