背景
The modification of proteins with ubiquitin is an important cellular mechanism for targeting
abnormal or short-lived proteins for degradation. Ubiquitination involves at least three
classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or
E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation
factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest
candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript
variants encoding distinct isoforms have been found for this gene
