免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 2900-3050
of human RANBP2
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358; RANBP2
背景
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear
membrane and is thought to control a variety of cellular functions through its interactions
with other proteins. This gene encodes a very large RAN-binding protein that
immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic
cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein
directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from
UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic
filaments of the nuclear pore complex and suggest that, for some substrates, modification
and nuclear import are linked events. This gene is partially duplicated in a gene cluster that
lies in a hot spot for recombination on chromosome 2q
