背景
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC
chemokine family. This growth factor is a potent chemoattractant and activator of
neutrophils. It has been shown to stimulate various cellular processes including DNA
synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion,
and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the
formation and secretion of plasminogen activator by synovial cells. The protein also is an
antimicrobial protein with bactericidal and antifungal activity
