背景
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and
metalloproteinase with thrombospondin motifs) family. Members of this family share several
distinct protein modules, including a propeptide region, a metalloproteinase domain, a
disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this
family differ in the number of C-terminal TS motifs, and some have unique C-terminal
domains. The encoded preproprotein is proteolytically processed to generate the mature
enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth
muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility
to coronary artery disease.
