基因名称(Gene Name)
PQBP1 NPW38 JM26
蛋白名称
Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)
免疫原
Synthesized peptide derived from human PQBP1
特异性
This antibody detects endogenous levels of PQBP1 at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development . Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species . May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery . May be involved in ATXN1 mutant-induced cell death . The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit . Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules . Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol . Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production .
