背景
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic
reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds
estrogen and activates multiple downstream signaling pathways, leading to stimulation of
adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular
calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the
nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely
observed following stimulation of cells and tissues with estrogen. This receptor has been
shown to play a role in diverse biological processes, including bone and nervous system
development, metabolism, cognition, male fertility and uterine function.
