免疫原
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human
ACC1 (Q13085)
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
其他名称
ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha
背景
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotincontaining enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by
two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under
long term control at the transcriptional and translational levels and under short term
regulation by the phosphorylation/dephosphorylation of targeted serine residues and by
allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript
variants divergent in the 5' sequence and encoding distinct isoforms have been found for
this gene.
