蛋白名称
Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13)
免疫原
Synthesized peptide derived from human YTHDC2
特异性
This antibody detects endogenous levels of YTHDC2 at Human, Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
3'-5' RNA helicase YTHDC2;EC:3.6.4.13;hYTHDC2;YTH domain-containing protein 2;YTHDC2;Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13)
功能
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease . Required for both spermatogenesis and oogenesis (By similarity).
