免疫原
Purified recombinant EpCAM protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of EpCAM and does not cross-react with related proteins.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
其他名称
17 1A;323/A3;Adenocarcinoma associated antigen;Adenocarcinoma-associated antigen;Antigen identified by monoclonal antibody AUA1;AUA1;CD326;CD326 antigen;Cell surface glycoprotein Trop 1;Cell surface glycoprotein Trop 2;Cell surface glycoprotein Trop-1;CO 17A;CO17 1A;CO17A;DIAR5;EGP 2;EGP;EGP2;EGP314;EGP4;Ep CAM;Ep-CAM;EPCAM;EPCAM_HUMAN;EpCAM1;Epithelial cell adhesion molecule;Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD);Epithelial cell surface antigen;Epithelial cellular adhesion molecule;Epithelial glycoprotein 1;Epithelial glycoprotein 314;Epithelial glycoprotein;ESA;GA733 1;GA733 2;GA733-2;gastrointestinal tumor-associated antigen 2;35-KD glycoprotein;gp4;hEGP 2;hEGP314;HNPCC8;Human epithelial glycoprotein 2;KS 1/4 antigen;KS1/4;KSA;Ly74;Lymphocyte antigen 74;M1S 1;M1S2;M4S1;Major gastrointestinal tumor associated protein GA733 2;Major gastrointestinal tumor-associated protein GA733-2;mEGP314;Membrane component chromosome 4 surface marker (35kD glycoprotein);Membrane component;chromosome 4;surface marker 1;surface marker;MIC18;MK 1;Protein 289A;TACD1;TACSTD1;TROP1;Tumor associated calcium signal transducer 1;Tumor associated calcium signal transducer 2 precursor;Tumor-associated calcium signal transducer 1;EGP40;Membrane component chromosome 4 surface ma; 35-KD glycoprotein
背景
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008],
