蛋白名称
Dopamine beta-hydroxylase
免疫原
The antiserum was produced against synthesized peptide derived from human DBH. AA range:401-450
特异性
DBH Monoclonal Antibody detects endogenous levels of DBH protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
DBH; Dopamine beta-hydroxylase; Dopamine beta-monooxygenase
背景
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008],
功能
catalytic activity:3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)O.,cofactor:Binds 1 PQQ per subunit.,cofactor:Binds 2 copper ions per subunit.,disease:Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.,function:Conversion of dopamine to noradrenaline.,induction:Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.,online information:Dopamine beta hydroxylase entry,pathway:Catecholamine biosynthesis; norepinephrine biosynthesis; norepinephrine from dopamine: step 1/1.,polymorphism:
