基因名称(Gene Name)
LCMT2 KIAA0547 TYW4
免疫原
Synthesized peptide derived from human LCMT2 AA range: 298-348
特异性
This antibody detects endogenous levels of LCMT2 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008],
功能
function:Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.,pathway:tRNA modification; wybutosine-tRNA(Phe) biosynthesis.,similarity:Belongs to the methyltransferase superfamily. LCMT family.,subunit:Interacts with RNF144B/IBRDC2.,
