基因名称(Gene Name)
ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924
免疫原
Synthesized peptide derived from human ERLN2 AA range: 239-289
特异性
This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012],
功能
function:Plays an important role in the early steps of the endoplasmic reticulum-associated degradation (ERAD) pathway. Involved in ITPR1 degradation by the ERAD pathway.,similarity:Belongs to the band 7/mec-2 family.,subcellular location:Associated with lipid raft-like domains of the endoplasmic reticulum membrane.,subunit:Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination.,tissue specificity:Ubiquitous.,
