免疫原
Synthesized peptide derived from human NH2L1 AA range: 33-83
特异性
This antibody detects endogenous levels of NH2L1 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
功能
function:Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.,similarity:Belongs to the ribosomal protein L7Ae family.,subcellular location:Concentrated in the dense fibrillar component of the nucleolus.,subunit:Interacts with RAD17.,tissue specificity:Ubiquitous.,
