基因名称(Gene Name)
PUS10 CCDC139 DOBI
免疫原
Synthesized peptide derived from human PUS10 AA range: 425-475
特异性
This antibody detects endogenous levels of PUS10 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009],
功能
catalytic activity:tRNA uridine = tRNA pseudouridine.,function:Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Partially unspliced pre-RNA.,similarity:Belongs to the pseudouridine synthase Pus10 family.,
