免疫原
Synthesized peptide derived from human SPRE2 AA range: 68-118
特异性
This antibody detects endogenous levels of SPRE2 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008],
功能
function:Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.,PTM:Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination.,PTM:Ubiquitinated; leading to degradation by the proteasome.,similarity:Contains 1 KBD domain.,similarity:Contains 1 SPR (sprouty) domain.,similarity:Contains 1 WH1 domain.,subcellular location:Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.,subunit:Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers.,tissue specificity:Expressed in liver, skin, small intestine, salivary gland and prostate.,
