免疫原
Synthesized peptide derived from human FHL5 AA range: 129-179
特异性
This antibody detects endogenous levels of FHL5 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016],
功能
function:May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.,similarity:Contains 4 LIM zinc-binding domains.,subcellular location:Nuclei of round and elongated spermatids.,subunit:Interacts with CREM via the third LIM domain.,tissue specificity:Testis-specific (at protein level).,
