基因名称(Gene Name)
MTHFD2 NMDMC
免疫原
Synthesized peptide derived from human MTDC AA range: 121-171
特异性
This antibody detects endogenous levels of MTDC at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009],
功能
catalytic activity:5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.,catalytic activity:5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.,cofactor:Magnesium.,developmental stage:Expressed only in developing normal tissues.,miscellaneous:This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.,similarity:Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.,subunit:Homodimer.,
