基因名称(Gene Name)
VPS37C PML39
免疫原
Synthesized peptide derived from human VP37C AA range: 220-270
特异性
This antibody detects endogenous levels of VP37C at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008],
功能
function:Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.,similarity:Belongs to the VPS37 family.,similarity:Contains 1 VPS37 C-terminal domain.,subcellular location:Probably associates with membranes. Recruited to the plasma membrane by HIV-1.,subunit:Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, FAM125A and FAM125B. Interacts with HGS and STAM2. Interacts with CEP55.,
