基因名称(Gene Name)
TWF1 PTK9
免疫原
Synthesized peptide derived from human TWF1 AA range: 179-229
特异性
This antibody detects endogenous levels of TWF1 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008],
功能
caution:Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity.,function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.,online information:Molecular embrace -Issue 73 of August 2006,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.,similarity:Contains 2 ADF-H domains.,subcellular location:Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.,subunit:Interacts with G-actin; ADP-actin form and capping protein (CP).
