基因名称(Gene Name)
CKAP5 KIAA0097
免疫原
Synthesized peptide derived from human CKAP5 AA range: 1446-1496
特异性
This antibody detects endogenous levels of CKAP5 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
功能
function:Plays a major role in organizing spindle poles.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the TOG/XMAP215 family.,similarity:Contains 10 HEAT repeats.,subunit:Interacts with TACC1.,tissue specificity:Over-expressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas.,
