基因名称(Gene Name)
FIG4 KIAA0274 SAC3
免疫原
Synthesized peptide derived from human FIG4. at AA range: 341-390
特异性
This antibody detects endogenous levels of FIG4
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)
背景
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008],
功能
phospholipid metabolic process, glycerophospholipid metabolic process, vacuole organization, behavior, locomotory behavior, cell death, death, organophosphate metabolic process, neuron differentiation, phosphoinositide metabolic process, pigmentation, glycerolipid metabolic process, neuron development,
