储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
背景
The protein encoded by this gene is a cytokine that regulates T and natural killer cell
activation and proliferation. This cytokine and interleukine 2 share many biological activities.
They are found to bind common hematopoietin receptor subunits, and may compete for the
same receptor, and thus negatively regulate each other's activity. The number of CD8+
memory cells is shown to be controlled by a balance between this cytokine and IL2. This
cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation
of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart
suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCLx(L), possibly through the transcription activation activity of STAT6, and thus prevent
apoptosis. Alternatively spliced transcript variants of this gene have been reported.
