蛋白名称
Coiled-coil domain-containing protein 74A
免疫原
Synthesized peptide derived from human CC74A AA range: 38-88
特异性
This antibody detects endogenous levels of human CC74A
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008],
功能
function:May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.,PTM:N-glycosylated.,similarity:Belongs to the CREG family.,subunit:Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.,
