基因名称(Gene Name)
NUDT22 PP11246
蛋白名称
Nucleoside diphosphate-linked moiety X motif 22 (Nudix motif 22)
免疫原
Synthesized peptide derived from human NUD22 AA range: 44-94
特异性
This antibody detects endogenous levels of human NUD22
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
disease:May be associated with Usher syndrome type IA (USHA1A) which describes a congenital sensory deafness associated with retinitis pigmentosa and feeble-mindedness.,function:Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.,similarity:Contains 1 DSL domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 16 EGF-like domains.,tissue specificity:Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.,
