蛋白名称
Protein FRG1 (FSHD region gene 1 protein)
免疫原
Synthesized peptide derived from human FRG1 AA range: 184-234
特异性
This antibody detects endogenous levels of human FRG1
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
function:Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.,similarity:Contains 1 thioredoxin domain.,subcellular location:In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.,tissue specificity:Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.,
功能
function:Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.,similarity:Contains 1 thioredoxin domain.,subcellular location:In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.,tissue specificity:Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.,
