基因名称(Gene Name)
ARPC2 ARC34 PRO2446
蛋白名称
Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
免疫原
Synthesized peptide derived from human ARPC2 AA range: 147-197
特异性
This antibody detects endogenous levels of human ARPC2
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-58 is the initiator.,cofactor:Calcium.,function:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.,miscellaneous:Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.,sequence caution:The first part of the cDNA maps to the same locus, but in opposite orientation.,similarity:Contains 1 PPIase FKBP-type domain.,similarity:Contains 3 TPR repeats.,subunit:Homomultimers or heteromultimers (Potential). Forms heterodime
