蛋白名称
Protein FRG2-like-1 (FSHD region gene 2 protein family member B) (HSA10-FRG2)
免疫原
Synthesized peptide derived from human FRG2B AA range: 196-246
特异性
This antibody detects endogenous levels of human FRG2B
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011],
功能
catalytic activity:Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the peptidase M12A family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 MATH domain.,subunit:Homotetramer of alpha or beta subunits; heterotetramer of two alpha and two beta subunits are formed by non-covalent association of two disulfide-linked heterodimers.,
