基因名称(Gene Name)
AFF2 FMR2 OX19
蛋白名称
AF4/FMR2 family member 2 (Fragile X E mental retardation syndrome protein) (Fragile X mental retardation 2 protein) (FMR2P) (Protein FMR-2) (Protein Ox19)
免疫原
Synthesized peptide derived from human AFF2 AA range: 1104-1154
特异性
This antibody detects endogenous levels of human AFF2
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012],
功能
catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.,caution:It is uncertain whether Met-1, Met-6 or Met-20 is the initiator.,disease:Candidate gene for the breast cancer locus on chromosome 8p12-p22.,function:Probable glycosyltransferase.,online information:Exostosin-like 3,online information:GlycoGene database,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the glycosyltransferase 47 family.,tissue specificity:Ubiquitous.,
