基因名称(Gene Name)
BPIFB6 BPIL3
蛋白名称
BPI fold-containing family B member 6 (Bactericidal/permeability-increasing protein-like 3)
免疫原
Synthesized peptide derived from human BPIB6 AA range: 268-318
特异性
This antibody detects endogenous levels of human BPIB6
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA cod
功能
catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Protects the hemoglobin in erythrocytes from oxidative breakdown.,online information:Glutathione peroxidase entry,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer.,
